Modeling of main arteries restenosis in experimental cardiology

Abstract Funding Acknowledgements Type of funding sources: None. Purpose To perform the model main arteries restenosis and to study arterial hemodynamics using original device for modeling intra-arterial circulation. Materials methods We used an developed by us The part is a prototype human vessel - rotameter glass tube 365 mm length, with inlet diameter more than outlet (20 vs 16.5 mm). An aqueous solution glycerin introduced inside closed system had same viscosity as blood. Flexible silicone tubes are connected electric pump various modes work (imitation pulse waves in regular rhythm (RR), extrasystoles (ES), atrial fibrillation (AF)). hermetically installed imitation stent – metal construction spiral oriented parts 68 long. Plastic diaphragms 15 long stenosis internal lumen 50%, 70%, 90% were alternatively put hemodynamics. 5 silk thread was alternately tube, intravascular piezoelectric crystal pressure sensor oscilloscope injected dye clerical ink. Results When imitating AF after pause speed fluid flow through increased comparison RR pendency: if longer increased. So, 50%: 2.09 m/s, <1 s 3.36 >1, but <2 4.97 >2 5.88 m/s; 70% stenosis: 3.24 m/s 3.96 5.87 7.83 stenosis, at 8.96 9.46 11.17 13.45 m/s. measured piezoelectrical probe proportionally speed. observed appearance reflected, standing edge zones diaphragm turbulent liquid behind stent. Conclusion These changes characterized proposed concept "hydraulic shock". Intense mechanical effect pauses between cardio cycles marginal can cause further growth, progression atherosclerosis vessels.